Test of Cure: Use of Human Papillomavirus (HPV) testing to optimize the cervical cancer screening clinical pathway post-treatment

Dr. Kopciuk

The results of this project will inform the implementation of HPV test of cure to optimize the clinical follow-up pathway for Cervical Intraepithelial Neoplasia (CIN) post-treatment, which will improve patient outcomes in Alberta, reduce variability in clinical practice, reduce wait times for colposcopy, and reduce related health care costs …

An overall workflow for the development of a multivariate model for prognostication of cancers

Dr. Kopciuk

We exploited a number of contemporary statistical concepts and programming languages, high-performance computing, and a traditional Cox PH regression survival analysis to create a workflow for finding genes associated with survival outcomes. Our workflow explores a high-dimensional dataset …

Development, Application and Evaluation of Multistate Models for Risk Estimation and Screening Interventions in Lynch Syndrome Families and Familial Colorectal Cancer Type X Families

Dr. Kopciuk

This project is estimating the lifetime effect of screening on disease outcomes in LS and FCCTX families, stratifying families based on the predicted screening efficiency …

Determinants of cancer stage at diagnosis

Dr. Kopciuk

This project will explore factors associated with early stage of cancer at diagnosis, using data from Alberta’s Tomorrow Project The specific aims are to: (1) develop multivariable regression models using ordinal logistic regression to identify independent and synergistic factors (clinical, lifestyle, screening, etc.) associated with cancer stage at diagnosis; (2) develop spatial regression models to account for geographic and other factors …

Breast Cancer to Bone (B2B) Metastases Research Program

Dr. Kopciuk and Dr. Friedenreich

The B2B research program established a cohort newly diagnosed breast cancer cases with the objective of studying how breast cancer metastasizes to the bone. This cohort study has involved several sub-projects including one currently led by Dr. Kopciuk to investigate the impact of vitamin D and markers of inflammation in breast cancer metastases. Other projects…

Colorectal Cancer Lifestyle & Environment in Alberta Research (CLEAR) Study

Dr. Kopciuk

Dr. Brockton and investigators from Alberta Health Services and the University of Calgary are studying lifestyle and environmental factors related to the progression of colorectal cancer. Using information from all colorectal cancer patients, they hope to learn more about why some colorectal cancers advance faster than others, and how this might be prevented. The spread…