The Endometrial Cancer Cohort study includes 540 incident cases of endometrial cancer that were diagnosed in Alberta between 2001-2006 who were initially part of a population-based case-control study of lifetime physical activity and endometrial cancer risk that we conducted that also included about 1000 controls. The cases were interviewed after their diagnoses, and again about two years post-diagnosis to assess their physical activity levels, diet, and other lifestyle, medical, hormonal and reproductive factors that might be related to their survival after endometrial cancer. Blood and tissue samples were collected in the case-control study, and several papers have been published that have examined the metabolic syndrome, insulin resistance, inflammation, sex hormones, dietary intake, alcohol and more analyses are on-going. The cases were being followed for recurrences, progressions and mortality outcomes to 2019. The survival analyses for this cohort have begun with investigations of pre- and post-diagnosis physical activity and the metabolic syndrome. Several on-going analysis of other risk factors and their association with survival outcomes are being conducted. We are collaborating with investigators around the world in the E2C2 consortium, and have contributed DNA and epidemiologic data for GWAS studies and other pooled analyses.
Co-investigators: Dr. Kerry Courneya, Dr. Linda Cook, Dr. Yutaka Yasui, Dr. David Lau
Funders: Canadian Cancer Society, Canadian Institutes of Health Research and Alberta Cancer Board