3 generation family

Dr. Friedenreich

The Endometrial Cancer Cohort study included 540 incident cases of endometrial cancer diagnosed in Alberta between 2001-2006 who were initially part of a population-based case-control study of lifetime physical activity and endometrial cancer risk conducted that also included about 1000 controls. The cases were interviewed after their diagnoses, and again about two years post-diagnosis to assess their physical activity levels, diet, and other lifestyle, medical, hormonal and reproductive factors that might be related to their survival after endometrial cancer. Blood and tissue samples were collected in the case-control study, and several papers were published that have examined the metabolic syndrome, insulin resistance, inflammation, sex hormones, dietary intake, alcohol and smoking. The cases were followed for recurrences, progressions and mortality outcomes to 2023. The survival analyses for this cohort examined the role of pre- and post-diagnosis physical activity, the metabolic syndrome, obesity, alcohol and smoking intake, dietary patterns, endogenous sex hormones, insulin resistance and inflammation and second primary cancers. We are collaborating with investigators around the world in the E2C2 consortium and have contributed DNA and epidemiologic data for GWAS studies and other pooled analyses.

Co-investigators: Dr. Kerry Courneya, Dr. Linda Cook

Funders: Canadian Cancer Society, Canadian Institutes of Health Research