Colorectal Cancer Risk Prediction Models

Dr. Brenner

We are currently developing and validating risk prediction models for colorectal cancer and adenomatous polyps within the colon. We are particularly interested in the relative contribution of established lifestyle (diet, NSAIDs, body mass, physical activity) and familial risk factors in contrast to biomarkers. Of particular interest are markers of DNA methylation and microRNAs …

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Lifestyle and Cancer Risk

Dr. Brenner

Dr. Brenner and his team are currently modeling the associations between lifestyle and environmental factors including: physical inactivity, obesity, tobacco consumption and exposure, dietary factors, alcohol consumption and environmental (air pollution, water contaminants, radon, UV radiation) factors on cancer incidence in several large cohort studies. We are presently conducting several large-scale analyses in the Alberta‚Äôs Tomorrow Project …

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Cancer Burden in Canada

Dr. Brenner

Dr. Brenner has been researching the impact of lifestyle, environment and infections on cancer burden in Alberta and Canada. This research interest has led to the development of multiple research projects that are focused on cancer prevention through burden quantification. Current projects in Alberta and at the national level are working to quantify the current and future (up to 2042) impact …

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Genomics of Early-Onset Adult Cancers

Dr. Brenner

Our research team if evaluating the genomic landscape of breast and colon tumors that occur in younger aged adults. In particular, we are focused on the mutational landscape of breast cancer in young women under 40 and colorectal cancers under aged 50. We are examining whether the genomic alterations observed in young patients differ from those of the general population …

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The ComPARe Project

Dr. Brenner and Dr. Friedenreich

This project is quantifying the number and proportion of incident cancer cases in Canada, now and to 20142, that could be prevented through changes in modifiable lifestyle and environmental exposures associated with cancer. The broad risk factor categories of interest are: tobacco exposure, dietary factors, physical activity, obesity, environmental factors, infectious diseases and hormonal therapies…

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